small molecule library 1280 fda- and ema-approved drugs from the prestwick chemical library  (Prestwick Chemical)

Journal: Cancers

Article Title: A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

doi: 10.3390/cancers14122832

Figure Lengend Snippet: Screening of the Prestwick Chemical Library. ( A ) Schematic workflow of the Prestwick Chemical Library screening. ( B ) Average luminescent fold-change over DMSO control of all 1200 compounds from NK92 + K562-NL condition are plotted (each drug is represented by a black dot). The screening was conducted in singlet, over two biological replicates. The dotted red line indicates 1.3 fold-change. Compounds with a luminescent fold-change over DMSO control ≥ 1.3 were considered enhancers of NK92 cytotoxicity. Points represent the average fold-change of n = 2 biological replicates, except points 321–400 and 481–560 which represent fold-change from one replicate.

Article Snippet: We tested 1200 FDA approved drugs from the Prestwick Chemical Library, to identify compounds that increase NK cells’ cytotoxic potential.

Techniques: Library Screening, Control

Journal: Cancers

Article Title: A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

doi: 10.3390/cancers14122832

Figure Lengend Snippet: Compounds identified as enhancers of NK92 cytotoxicity from screening the Prestwick Chemical Library. Listed drugs had a luminescent fold-change ≥ 1.3 on both screening days. Drug class for each compound is listed. a Candidate drugs that were selected for further investigation. b Fold-change of single screening.

Article Snippet: We tested 1200 FDA approved drugs from the Prestwick Chemical Library, to identify compounds that increase NK cells’ cytotoxic potential.

Techniques: